![]() Among the many antioxidants previously studied (, ), recent studies suggest that caffeine can also inhibit such photochemical damage and cataract formation induced by UV irradiation (, ). The significance of light penetration in the eye and cataract development has also been corroborated by epidemiological data showing that about 20% of cataract blindness or visual impairment is globally related to intraocular UV penetration (Taylor et al, ). The reactions are driven pseudo-catalytically by absorption of light by the endogenous chromophores (, ). While oxidative stress has been suggested to be involved in the pathophysiology of many age dependent disabling manifestations including the extra-ocular ones, its role is considered particularly significant in lens and cataract formation because of a continued intra-ocular production of reactive oxygen species (ROS) due to the continued light penetration in the eye during the long periods of photopic vision and consequently an incessant generation of ROS. Introduction Oxidative stress has been implicated as one of the major contributors of cataract formation associated with aging and certain genetic diseases such as diabetes and galactosemia.
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